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Using a nodeset in a pre-run calibration

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I have a large circuit that has a long and complex calibration sequence and I have written a pre-run script for it. I am trying to cut down simulation time (currently takes 2 days in POLO), and I see that each iteration takes about 20 minutes for calculating the initial condition, and 20 minutes for transient.  My first thought was to use a nodeset to help for IC, but I am a little unsure, because every iteration of the simulation changes a control, which makes a (significant?) change to the circuit, and I don't want to bring the circuit to a bad operating point because of it.


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